- CAP（美国病理学家协会）2026-10-27 宣布：2027 年 PT 目录新增「基于甲基化的肿瘤分类」（Methylation-based Tumor Classification，MTC）项目，在线、基于文件参评，初期聚焦中枢神经系统肿瘤。
- 形式：计算机模拟（in silico）——CAP 下发 Illumina 甲基化芯片原始 IDAT 文件（单个 14 MB–1 GB），实验室导入本实验室的甲基化分类器完成分析并出具报告；不寄送实物样本。
- 频次：每批 2 个考核样本，每年两批（A 批 3 月 15 日、B 批 10 月 18 日）。
- 意义：CNS 肿瘤甲基化分类已成为常规诊断工具，此前缺少标准化的外部质控；该项目考核的是分类器与数据分析流程本身，开展甲基化检测的科室可据此规划 2027 年室间质评。
收录范围：CAP 官方 X 账号 @Pathologists 2026-10-27 推文及配图，CAP eStore 项目页（2027 Surveys / New Programs，「MTC」）中公开的项目说明、发放频次与时间表，中英对照。项目价格与订购需登录，未收录。
CAP 在 X 上的发布（2026-10-27）
2027 年新项目：CAP 基于甲基化的肿瘤分类（MTC）能力验证（PT）项目采用在线、基于文件的参评方式，初期聚焦中枢神经系统肿瘤。
项目页面（CAP eStore，2027 年调查 / 新项目）
| 分析项目 / 检测程序 | 每次发放的考核样本数 | 发放次数 |
|---|---|---|
| 基于甲基化的肿瘤分类 | 2 | 每年发放两次 |
补充说明
本项目为计算机模拟（in silico）项目，用 Illumina 甲基化芯片产生的 IDAT 文件，对基于甲基化的肿瘤分类器进行能力验证。目前这一方法最常见的应用是中枢神经系统肿瘤的分类。
项目信息
参评实验室下载 IDAT 文件，导入本实验室的甲基化分类器进行分析并出具报告；文件大小 14 MB 至 1 GB 不等。
发放时间表
- A 批：3 月 15 日
- B 批：10 月 18 日
页面同时列出的相关项目（「购买此项目的客户还购买了」）：实体瘤拷贝数变异、胶质瘤、微卫星不稳定性、肿瘤突变负荷。
- On 27 October 2026 the College of American Pathologists announced a new 2027 proficiency testing program, Methylation-based Tumor Classification (MTC), with online, file-based participation and an initial focus on central nervous system tumours.
- Format: in silico — laboratories download IDAT files generated from Illumina methylation arrays (14 MB to 1 GB each) and run them through their own methylation classifier for analysis and reporting; no physical specimens.
- Frequency: 2 challenges per shipment, two shipments a year (Shipment A 15 March, Shipment B 18 October).
- Why it matters: methylation classification is now routine in CNS tumour diagnosis but has lacked standardized external quality assessment; this program tests the classifier and analysis pipeline itself.
Scope: the 27 October 2026 post and graphic from the CAP account @Pathologists on X, and the publicly visible program description, shipment frequency and schedule on the CAP eStore product page (2027 Surveys / New Programs, “MTC”). Pricing and ordering require login and are not included.
CAP post on X (27 October 2026)
New for 2027: The CAP’s Methylation-based Tumor Classification (MTC) PT program offers online, file-based participation, with an initial focus on central nervous system tumors.
Program page (CAP eStore, 2027 Surveys / New Programs)
| Analyte/Procedure | Challenges per Shipment | Number of Shipments |
|---|---|---|
| Methylation-based tumor classification | 2 | Two shipments per year |
Additional Information
This in silico program is designed for proficiency testing of methylation-based tumor classifiers using IDAT files generated from Illumina methylation arrays. Currently, the most common application of this methodology is in the classification of central nervous system tumors.
Program Information
IDAT files to be downloaded and incorporated into your laboratory methylation classifier for analysis and reporting; file sizes range from 14 MB to 1 GB.
Shipping Schedule
- Shipment A: March 15
- Shipment B: October 18
Related programs listed on the page (“Customers who bought this item also bought”): Copy Number Variant Solid Tumor; Glioma; Microsatellite Instability; Tumor Mutational Burden.